ZIA CP010145-07040 (ZIA) | |||
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Title | Breast imaging studies in women at high genetic risk of breast cancer | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Loud, Jennifer | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $454,638 | Project Dates | 00/00/0000 - 00/00/0000 |
Fiscal Year | 2013 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Basic Behavioral and Social Science (25.0%) Behavioral and Social Science (25.0%) Biochemical Epidemiology (45.0%) Cancer (100.0%) Chemoprevention (50.0%) |
Breast (85.0%) Ovarian Cancer (15.0%) |
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Research Type | |||
Interventions to Prevent Cancer: Personal Behaviors That Affect Cancer Risk | |||
Abstract | |||
The Breast Imaging Study enrolled 200 women with, or at high risk of carrying, a germline BRCA1/2 mutation, in a 4-year prospective cohort study. Each participant underwent annual mammography, breast MRI, breast duct lavage (BDL), serum CA-125 and transvaginal ultrasound. Enrollment ended in March 2007; follow-up ended in May 2010. Changes in mammographic density and MRI fibroglandular volume are being evaluated, seeking associations with known breast cancer risk factors and medical/ lifestyle decisions made by the study participants. Breast imaging characteristics and molecular changes in breast duct epithelial cells obtained from NAF and BDL are being correlated to determine if cellular, molecular, proteomic or genomic changes can be defined in pre-malignant, pre-invasive and invasive breast cancer. The study has evaluated the psychosocial impact of being a member of a BRCA-positive family, leading to several publications on family communications within BRCA-positive families, the experience of being mutation-negative within a BRCA-positive family, and the tolerability of new breast cancer screening techniques. We have reported correlates of breast epithelial cell counts in BDL fluid, and the lack of mammographic density differences between mutation carriers and non-carriers. We are collaborating with investigators at the University of Chicago to evaluate novel digitized mammogram imaging features as predictors of breast cancer risk. In addition, the study provides biospecimens for research collaborations within the Consortium of Investigators of Modifiers of BRCA. Manuscripts are under review related to the detection of estrogen metabolites in breast duct lavage and nipple aspirate fluid and mammographic texture as a novel indicator related to increased breast cancer risk. |